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Fluvastatin 93957-55-2 CAS NO.93957-55-2
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T,Other
- Available Specifications:
- Product Details
Keywords
- 6-Heptenoicacid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-,monosodium salt, (3R,5S,6E)-rel- (9CI)
- Fluvastatin sodium salt
- 93957-55-2
Quick Details
- ProName: Fluvastatin sodium
- CasNo: 93957-55-2
- Molecular Formula: C24H25FNNaO4
- Appearance: White crystallization
- Application: Cardiovascular APIs,Sartan antihyperte...
- DeliveryTime: in two weeks
- PackAge: 25kg/drum
- Port: SHANGHAI BEIJING
- ProductionCapacity: 10 Metric Ton/Day
- Purity: USP/EP/BP
- Storage: room temperature
- Transportation: AIR SEA TRAIN
- LimitNum: 1 Kilogram
Superiority
We are very compeitive on Fluvastatin sodium salt.Our mfr is GMP certified for this item with DMF document.
| Product Name: | Fluvastatin sodium salt |
| Synonyms: | sodium (3r,5s,6e)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl]-3,5-dihydroxy-6-heptenoate;(+/-)-(3R',5S',6E)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYLINDOL-2-YL]-3,5-DIHYDROXY-6-HEPTENOATE, SODIUM;FLUVASTATIN NA;FLUVASTATIN SODIUM;FLUVASTATIN SODIUM SALT;(r*,s*-(e))-monosodiumsal(+-)-2-yl);3,5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-6-heptenoicaci;5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl)-monosodiumsalt,(r*,s*-(e))-(6-heptenoicaci |
| CAS: | 93957-55-2 |
| MF: | C24H25FNNaO4 |
| MW: | 433.45 |
| EINECS: | 1308068-626-2 |
| Product Categories: | HMG-CoA reductase;Antihyperlipoproteinemic;Intermediates & Fine Chemicals;Pharmaceuticals;API Reference Standard;API |
| Mol File: | 93957-55-2.mol |
| Fluvastatin sodium salt Chemical Properties |
| Melting point | 194-197°C |
| storage temp. | 2-8°C |
| solubility | H2O: ≥9mg/mL |
| form | powder |
| color | white to tan |
| Water Solubility | water: 30mg/mL DMSO: soluble methanol: soluble |
| Merck | 14,4218 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
Details
| Fluvastatin sodium salt Usage And Synthesis |
| Commonly used cholesterol-lowering drugs | Fluvastatin sodium salt is commonly used as a cholesterol-lowering drug, cholesterol-lowering effect is very good, the trade name of the commercially available products is Lescol,which is produced by Novartis. Fluvastatin sodium salt is a fully synthetic cholesterol-lowering drug, it belongs to methylglutaryl coenzyme A (HMC-CoA) reductase inhibitors, the main function is performed in the liver ,it can transform HMG-CoA into 3-methyl-3,5-dihydroxy acid, it can inhibit the synthesis of endogenous cholesterol ,and reduce cholesterol content in liver cells, it can stimulate the synthesis of low density lipoprotein (LDL) receptors,and enhance the uptake of LDL particles, reduce the plasma total cholesterol concentration.it can significantly reduce total cholesterol, LDL cholesterol, triglycerides, and increase high-density lipoprotein cholesterol. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | Melting point 194~197 ℃. |
| Uses | HMG-CoA reductase inhibitors. |
| production method | 1. After condensation of (chloroacetyl) fluorobenzeneand N-isopropyl aniline , the compound (I) is obtained. Then in acetonitrile, under the presence of phosphorus oxychloride, react with N, N-dimethylamino acrolein , the compound (Ⅱ) is obtained. Compound (Ⅱ) in the role of a strong base, after condensation with methyl acetoacetate , and then splitting ,the compound (Ⅲ) is produced. At-77 ~-74 ℃, the compound (Ⅲ) is added dropwise into a mixture of boron sodium borohydride , methanol, tetrahydrofuran and diethyl methoxy ,stir 30min; cyclic boronic ester obtained in ethyl acetate is treated with 30% hydrogen peroxide; then it is hydrolyzed to obtain fluvastatin sodium. 2. the compound (Ⅳ)is obtained by catalytic hydrogenation of Phloroglucinol . React it With tert-butyldiphenylsilyl chloride to produce the compound (V), and then oxidize it to generate (Ⅵ). After oxidation of chloroperbenzoic acid to obtain (Ⅶ), (Ⅷ) is produced through ring-opening . And then it is oxidized to (IX) . (Ⅺ) is obtained through condensation of (Ⅸ) and intermediate x , after deprotection and hydrolysis, obtain fluvastatin sodium. Intermediate (X) can be made through starting from the compound (I), via formylation, reduction, chlorination, and then reacting with triphenylphosphine . |
| Description | Fluvastatin sodium is the fourth HMG-CoA reductase inhibitor to reach the market as a dietary adjunct for lowing total and low-density lipoprotein (LDL) cholesterol. Fluvastatin sodium is the first totally synthetic inhibitor of its class and has more potent effects on reducing serum total and LDL cholesterol and serum triglyceride levels than compactin or lovastatin. Moreover, fluvastatin exhibits a unique set of pharmacological properties including a biopharmaceutical profile most consistent with hepatoselectivity. It has been reported to be well tolerated and to exhibit a safety profile superior to other agents of its class. The main mechanism by which HMG-CoA reductase inhibitors lower plasma cholesterol has been suggested to be up-regulation of hepatocellular LDL-receptor expression and enhancement of receptor-mediated clearance and catabolism of LDL cholesterol. |
| Chemical Properties | Yellow Powder |
| Originator | Sandoz (Switzerland) |
| Uses | Anti- hyperlipoproteinemic;'HMG CoA reductase inhibitor |
| Uses | Fluvastatin-d6 Sodium Salt is the labeled analogue of Fluvastatin Sodium Salt (F601250), a synthetic HMG-CoA reductase inhibitor. Antilipemic. |
