Intermediate of enzalutamide 915087-25-1 CAS NO.915087-25-1

Product Name:	4-amino-2-fluoro-N-methylbenzamide
Synonyms:	4-AMINO-2-FLUORO-N-METHYLBENZAMIDE;N-Methyl-2-fluoro-4-aminobenzamide;BenzaMide, 4-aMino-2-fluoro-N-Methyl-;2. 4-aMino-2-fluoro-N-MethylbenzaMide;N-Methyl-4-amino-2-fluoro-benzamide;4-amino-2-fluoro-N-menthylbenzamide;Enzalutamide Impurity 20;Enzalutamide ITS-3
CAS:	915087-25-1
MF:	C8H9FN2O
MW:	168.17
EINECS:
Product Categories:	915087-25-1
Mol File:	915087-25-1.mol

4-amino-2-fluoro-N-methylbenzamide Chemical Properties

Melting point	160 - 163°C
Boiling point	320℃
density	1.234
Fp	147℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	14.12±0.46(Predicted)
color	White to Off-White

Safety Information

HS Code

2924297099

MSDS Information

4-amino-2-fluoro-N-methylbenzamide Usage And Synthesis

Uses	4-amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors.
Description	4-amino-2-fluoro-N-methylbenzamide is a novel antiandrogen drug MDV (Marek's Disease Virus) 3100 key intermediate which is the new generation oral androgen antagonist medicine of united states drug developer Medivation company exploitation, be mainly used in treating advanced prostate cancer (CRPC) patient.
Preparation	2-fluoro-4-nitrotoluene as raw material, through potassium permanganate oxidation, the thionyl chloride chlorination, methylamine amination, and Pd/C hydrogenation reduction prepare 4-amino-2-fluoro-N-methylbenzamide.

4-amino-2-fluoro-N-methylbenzamide Preparation Products And Raw materials

Preparation Products