Intermediate of Fluzoparib CAS NO.763114-26-7

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Basic information

Product Name:	2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
Synonyms:	(2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylMethyl)benzoic acid)763114-26-7;2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)Methyl]benzoic acid;Benzoic acid, 5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluoro-;2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl);5-[(3,4-Dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluoro-Benzoic acid;2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid;EOS-61877
CAS:	763114-26-7
MF:	C16H11FN2O3
MW:	298.27
EINECS:	800-110-6
Product Categories:
Mol File:	763114-26-7.mol

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Chemical Properties

density	1.42
storage temp.	Sealed in dry,Room Temperature
pka	3.19±0.10(Predicted)
form	powder
color	White to off-white

Safety Information

HS Code

2916399090

MSDS Information

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Usage And Synthesis

Uses	2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate used in the synthesis of phthalazinone scaffolds that are potent inhibitors of poly(ADP-ribose) polymerase, and also in the design of isocorydine derivatives with anticancer effect.
Uses	2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate used in the synthesis of phthalazinone scaffolds that are potent inhibitors of poly(ADP-ribose) polymerase, and also in the design of isocorydine derivatives with anticancer effect.
Application	2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate in the synthesis of olaparib. Olaparib is a PARP polymerase inhibitor.
Synthesis	Compound 3 (2.6g, 0.011mol)And 2-fluoro-5-formylbenzoic acid (2.1g, 0.012mol)Dissolved in anhydrous tetrahydrofuran (25ml), cooled to 0 ,Slowly add triethylamine (1.0ml, 0.007mol) dropwise, then warm up to room temperature for 5h, then slowly raise the temperature to 70 , add hydrazine hydrate (5.1ml, 0.107mol) for 3h, and drop to room temperature , Add appropriate amount of hydrochloric acid (2mol / L) to adjust the pH to acidic, no longer precipitate solids. Filter with suction, wash the product with water and ethyl acetate, and dry to obtain a yellow solid (1.9g, yield 83%)

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Preparation Products And Raw materials

Raw materials	2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile-->2-Fluoro-5-formylbenzoic acid-->3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid-->2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile-->2-Carboxybenzaldehyde
Preparation Products	Fluzoparib-->AZD2461