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98% up Linagliptin 668270-12-0 CAS NO.668270-12-0
- FOB Price: USD: 825.00-1,100.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
99% up(1-5)Kilogram99% up(5-20)Kilogram99% up(20-100)Kilogram
- Product Details
Keywords
- Linagliptin 668270-12-0
- Linagliptin
- 668270-12-0
Quick Details
- ProName: 98% up Linagliptin 668270-12-0
- CasNo: 668270-12-0
- Molecular Formula: C25H28N8O2
- Appearance: Yellow powder
- Application: API
- DeliveryTime: in 7 days after your payment
- PackAge: 1kg/bag ;5kg/drum
- Port: Shanghai/Beijing/Hangzhou
- ProductionCapacity: 10 Metric Ton/Month
- Purity: 99% up
- Storage: low temperature storage
- Transportation: in low tempreture
- LimitNum: 1 Kilogram
Superiority
Why is SINOWAY:
1) Specialized in pharmaceutical and healthcare industrial for 34 years.
2) ISO 9001:2015 & SGS audited supplier .
3) Accept various payment terms : T.T 30-60 days.
4) We have warehouse in USA with quickly shipment .
5) We can do different terms of FOB ,CIF/CIP ,DDP ...
Details
|
Product name |
Linagliptin |
|
CAS No. |
668270-12-0 |
|
Molecular Formula |
C25H28N8O2 |
|
Molecular Weight |
472.55 |
|
Quality Standard |
98% up by HPLC |
|
Appearance |
Off-white to light-yellow crystalline powder |
|
|
|
ITEMS |
SPECIFICATION |
RESULT |
|
Appearance |
Off-white to light-yellow crystalline powder |
Light yellow crystalline powder |
|
Solubility |
Soluble in methanol and sparingly soluble in 2-propanol |
Conforms |
|
Identity |
(1) The infrared absorption spectrum of the sample in potassium bromide dispersion is concordant with that of a similar preparation of working standard. |
Conforms |
|
(2) The retention time of the main peak of testing solution should be confirmed with the reference solution in HPLC chromatogram. |
Conforms |
|
|
Melting point |
200.0 。C - 206.0。C |
203.0。C - 204.5。C |
|
Loss on drying |
≤ 1.0% |
0.38% |
|
Residual solvents |
Methanol ≤ 3000 ppm Isopropanol ≤ 5000 ppm DMF ≤ 880 ppm Dichloromethane ≤ 600 ppm |
ND 4621 ppm ND ND |
|
Residual on ignition |
≤ 0.1% |
0.08% |
|
Related substance |
Max single impurity ≤ 0.1% Total impurities ≤ 1.0% |
0.07% 0.21% |
|
Heavy metals |
≤ 10 ppm |
Conforms |
|
Isomer |
≤ 0.15% |
ND |
|
Assay |
98.0% - 102.0% |
99.89% |
|
Conclusion |
The sample complies with the above specification |
|
Linagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4), which degrades incretin-like polypeptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Linagliptin increases the concentration of active incretin hormones, stimulates insulin release in a glucose-dependent manner, and reduces circulating glucagon levels.
Linagliptin in combination with metformin and sulfonylureas, with diet and exercise, can be used for glycemic control in adults with type II diabetes.
