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Home > Products >  Hot Sale China Factory Direct Supply Antifungal Drugs Ketoconazole

Hot Sale China Factory Direct Supply Antifungal Drugs Ketoconazole CAS NO.65277-42-1

  • FOB Price: USD: 15.00-65.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T,Other
  • Available Specifications:

    Medicine Grade(1-99)KilogramMedicine Grade(100-1000)Kilogram

  • Product Details

Keywords

  • Ketoconazole
  • factory price
  • High purity 99%

Quick Details

  • ProName: Hot Sale China Factory Direct Supply A...
  • CasNo: 65277-42-1
  • Molecular Formula: C26h28cl2n4o4
  • Appearance: White powder
  • Application: Ketoconazole is an imidazole anti-fung...
  • DeliveryTime: in 7 days afte your payment ( in stock...
  • PackAge: 1kg/bag ;5kg/drum:25KG/drum
  • Port: any port in China
  • ProductionCapacity: 20 Metric Ton/Month
  • Purity: 99% up
  • Storage: in low tempreture
  • Transportation: in low tempreture
  • LimitNum: 1 Kilogram

Superiority

Why is SINOWAY:

1) Specialized in pharmaceutical and healthcare industrial for 34 years.

2) ISO 9001:2015 & SGS audited supplier . 

3) Accept various payment terms : T.T 30-60 days.

4) We have warehouse in USA with quickly shipment .

5) We can do different terms of FOB ,CIF/CIP ,DDP ...

Why choose us

1. best quality in your requirement
2. competitive price in china market
3. mature technical support
4. professional logistic support
5. full experience of large numbers containers loading in chinese sea port
6. fast shipment by reputed shipping line
7. packing with pallet as buyer's special request
8. best service after shipment with email !
9. cargoes together with container after-sales service available
10. full experience in export
11. raw materials from chinese origin

Details

Product Information

Ketoconazole Basic information
Product Name:                              Ketoconazole
Synonyms: ,3-dioxolan-4-yl)methoxy)phenyl)-,cis-;fungarest;fungoral;ketoconazol;ketoderm;ketoisdin;kw-1414;nizoral
CAS: 65277-42-1
MF: C26H28Cl2N4O4
MW: 531.43
EINECS: 265-667-4
Melting point                      146°C
Boiling point  753.4±60.0 °C(Predicted)                                                                                                  
density  1.4046 (rough estimate)
refractive index  -10.5 ° (C=0.4, CHCl3)
Fp  9ºC
storage temp.  2-8°C
solubility  methanol: soluble50mg/mL
pka pKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain)
form  Off-white solid
color  white to light yellow
optical activity [α]20/D -1 to 1°, c = 4 in methanol
Water Solubility  Soluble in DMSO, ethanol, chloroform, water, and methanol.

Usage 

Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.Target: CYP3A4 CYP24A1Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosteron levels, in men being treated for chronic mycotic infections [1]. Ketoconazole also is a cytochrome P450 inhibitor [2].Ketoconazole (KTZ), on the antischistosomal potential of these quinolines against Schistosoma mansoni infection by evaluating parasitological, histopathological, and biochemical parameters. Mice were classified into 7 groups: uninfected untreated (I), infected untreated (II), infected treated orally with PZQ (1,000 mg/kg) (III), QN (400 mg/kg) (IV), KTZ (10 mg/kg)+QN as group IV (V), HF (400 mg/kg) (VI), and KTZ (as group V)+HF (as group VI) (VII). KTZ plus QN or HF produced more inhibition (P<0.05) in hepatic CYP450 (85.7% and 83.8%) and CYT b5 (75.5% and 73.5%) activities, respectively, than in groups treated with QN or HF alone. This was accompanied with more reduction in female (89.0% and 79.3%), total worms (81.4% and 70.3%), and eggs burden (hepatic; 83.8%, 66.0% and intestinal; 68%, 64.5%), respectively, and encountering the granulomatous reaction to parasite eggs trapped in the liver.[3] CYP24A1 inhibitor enhances antiproliferative effects, increases systemic calcitriol exposure, and promotes the activation of caspase-independent apoptosis pathway.[4]

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