factory supply Midostaurin intermediate Staurosporine CAS NO.62996-74-1

Name: factory supply Midostaurin intermediate Staurosporine
SKU: 62996-74-1
Availability: InStock

We are very compeitive on Midostaurin .Our mfr is Chinese GMP certified for this item with DMF/CEP document.

It has a great function of potassium-sparing diuretics.

our advantage of Midostaurin

Product Name:	STAUROSPORINE
CAS:	62996-74-1
MF:	C28H26N4O3
MW:	466.54
EINECS:	613-127-7
Product Categories:	Inhibitor;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Signalling;Protein Kinase Inhibitors and Activators;Protein Kinase;antibiotic;API
Mol File:	62996-74-1.mol

Description	Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC₅₀ value of 2.7 nM. It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively. However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms. The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.
Chemical Properties	Light Yellow Solid
Occurrence	A complex alkaloid. staurosporine has been isolated from a strain of Streptomyces.
Uses	Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.
Uses	Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.