China (Mainland)
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The intermediate of Rilapladib CAS NO.623-00-7
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T,Other
- Available Specifications:
- Product Details
Keywords
- Benzonitrile, p-bromo-
- Rilapladib
- iptacopan
Quick Details
- ProName: 4-Bromobenzonitrile
- CasNo: 623-00-7
- Molecular Formula: C7H4BrN
- Appearance: White crystallization
- Application: Butyldimethylsilyloxyethylcarboxyet
- DeliveryTime: in two weeks
- PackAge: 25kg/drum
- Port: SHANGHAI BEIJING
- ProductionCapacity: 10 Metric Ton/Day
- Purity: 99.9% by HPLC
- Transportation: AIR SEA TRAIN
- LimitNum: 1 Kilogram
- Moisture Content: ≤0.5%
Superiority
| Product Name: | 4-Bromobenzonitrile |
| Synonyms: | PBBN;P-BROMOBENZONITRILE;4-BROMOBENZONITRILE FOR SYNTHESIS;4-Cyanophenyl bromide;p-Cyanobromobenzene;p-Cyanophenyl bromide;A nitrile of broMobenzene;Of broMoxynil |
| CAS: | 623-00-7 |
| MF: | C7H4BrN |
| MW: | 182.02 |
| EINECS: | 210-764-9 |
| Product Categories: | Building Blocks;C6 to C7;Phenyls & Phenyl-Het;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Nitrile;Nitriles;Miscellaneous;Bromine Compounds;Benzonitriles (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;Phenyls & Phenyl-Het;FINE Chemical & INTERMEDIATES;blocks;Bromides;Carboxes;Halides;C6 to C7;Cyanides/Nitriles;Nitrogen Compounds;bc0001 |
| Mol File: | 623-00-7.mol |
| 4-Bromobenzonitrile Chemical Properties |
| Melting point | 110-115 °C(lit.) |
| Boiling point | 235-237 °C(lit.) |
| density | 1,562 g/cm3 |
| refractive index | 1.5999 (estimate) |
| Fp | 130°C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 0.2g/l |
| form | Powder or Flakes |
| color | White to light yellow or flakes |
| Water Solubility | Very slightly soluble in water(0.2g/L). Soluble in alcohol and ether. |
| BRN | 2041518 |
| InChIKey | HQSCPPCMBMFJJN-UHFFFAOYSA-N |
| LogP | 2.3 at 22.5℃ and pH7 |
| CAS DataBase Reference | 623-00-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Bromobenzoic acid nitrile(623-00-7) |
| Safety Information |
| Hazard Codes | Xn,T,Xi |
| Risk Statements | 22-36/37/38-20/21/22 |
| Safety Statements | 61-36/37/39-26-24/25 |
| RIDADR | UN 3439 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | DI2460000 |
| Hazard Note | Toxic/Irritant |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29269095 |
Details
| 4-Bromobenzonitrile Usage And Synthesis |
| Chemical Properties | 4-Bromobenzonitrile is white to light yellow powder or flakes |
| Uses | 4- Bromobenzonitrile is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceu ticals and other organic chemicals, |
| Uses | 4-Bromobenzonitrile is used as reagents and solvents. Reaction of 2-propanol, 4-bromobenzonitrile, and NaH in the presence of 1.5 mol % Pd2(dba)3 and 3 mol % (S)-(-)2,2?-bis(di-p-tolylphosphino)- 1,1?-binaphthyl at 50°C afforded 4-isopropoxy- benzonitrile in 80% isolated yield. The synthesis of 4-cyanobiphenyl at room temperature in a flow injection microreactor, using a supported catalyst, without the addition of a base gave a product yield of 67±7% (n=6). This was achieved by injecting 4-bromobenzonitrile. The 3-arylation of 2,5-dimethylthiophene with 4-bromopropiophenone, 4-trifluoromethylbromobenzene or 4-bromobenzonitrile gave 3-5 in only 38-50% yields in Palladium-catalysed direct 3-or 4-arylation of thiophene derivatives using aryl bromides. |
| Synthesis Reference(s) | Tetrahedron Letters, 27, p. 1925, 1986 DOI: 10.1016/S0040-4039(00)84413-5 |
| Synthesis | To a 10 mL glass tube aryl halide (1 mmol), K4FeCN6 (0.6 mmol,220 mg), K2CO3 (1.5 mmol, 207 mg), catalyst (10 mg), and 2 mL DMF were added and the mixture was stirred for appropriate reaction time at 120 ℃ under argon atmosphere. The progress of the reaction was monitored by GC analysis. After completion of the reaction, the reaction mixture was washed with 5 mL water, and the crude product was isolated using dichloromethane (5× 1 mL). Organic extracts were combined, evaporated, and purified by flash chromatography using hexane/EtOAc to give 4-Bromobenzonitrile. |
| 4-Bromobenzonitrile Preparation Products And Raw materials |