Bethanechol 590-63-6 CAS NO.590-63-6

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Product Name:	Bethanechol
Synonyms:	(2-hydroxypropyl)trimethylammoniumchloridecarbamate;2-((aminocarbonyl)oxy)-n,n,n-trimethyl-1-propanaminiuchloride;2-[(aminocarbonyl)oxy]-n,n,n-trimethyl-1-propanaminiuchloride;ammonium,(2-hydroxypropyl)trimethyl-,chloride,carbamate;beta-methylcholinechlorideurethan;bethainecholinechloride;carbaminoyl,beta-methylcholinechloride;carbamyl-b-methylcholinechloride*crystalline
CAS:	590-63-6
MF:	C7H17ClN2O2
MW:	196.68
EINECS:	209-686-8
Product Categories:	Coumarins ,Pyrans;Inhibitors;DUVOID;Acetylcholine receptor;Aliphatics;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;590-63-6
Mol File:	590-63-6.mol

Bethanechol Chemical Properties

Melting point	187-190°C
storage temp.	Inert atmosphere,2-8°C
solubility	H₂O: 1.7 g/mL stable for several days at 4°C.
form	crystalline
color	white
Water Solubility	H2O: 1.7g/mL (stable for several days at 4°C.) ethanol: 80mg/mL (stable for several days at 4°C.)

Bethanechol Usage And Synthesis

Description	Bethanechol is an agonist of muscarinic acetylcholine receptors with IC₅₀ values of 1,837, 25, 631, 317, and 393 μM for M_1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M₂-mediated increases in cyclic AMP induced by isoproterenol in isolated guinea pig small intestine (IC₅₀ = 127 μM). Bethanechol increases basal tone of isolated porcine intravesical ureter (EC₅₀ = 4.27 μM). It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 μg/kg. Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.
Chemical Properties	White Solid
Originator	Urecholine CI,MSD,US,1949
Uses	cholinergic
Uses	A selective muscarinic receptor stimulant, used to treat cerebral palsy.
Uses	Therapeutic action of Betanechol is based on this action, and it is used for treating postoperational non-obstructive retention of urine and neurogenic bladder atony. Earlier, it was used for treating gastrointestinal illnesses and Alzheimer’s disease.