99% up chloroamphenicol powder 56-75-7 CAS NO.56-75-7

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Mycin has been widely used in the treatment of various sensitive bacterial infections, and since it has serious adverse reactions to the hematopoietic system, its clinical application has been strictly controlled. It can be used for typhoid fever, paratyphoid fever and rickettsial disease with specific effects and serious infections caused by sensitive bacteria. Chloramphenicol has a high concentration in the cerebrospinal fluid and is often used to treat meningitis patients with poor efficacy of other drugs. It can be administered by intravenous drip when necessary. Since chloramphenicol can cause serious side effects, it is only used clinically for typhoid fever caused by sensitive typhoid strains, influenza bacillus infection, severe Bacteroides fragilis infection, brain abscess, streptococcus pneumoniae or meningococcal meningitis, and penicillin Allergic patients. Avoid excessively long treatment courses during application, and patients with a history of hematological abnormalities caused by drugs should be contraindicated. All patients treated with chloramphenicol must be checked for white blood cells, reticulocytes and platelets at the beginning of treatment, and recheck every 3 to 4 days. If leukopenia occurs, the drug should be stopped immediately. Infants and young children should be very cautious when using chloramphenicol, unless there is no other drug substitution and must be used before consideration, and blood concentration monitoring can be performed when conditions permit.
Thiamphenicol and chloramphenicol are the same antibiotics, except that the nitro group on the benzene ring of chloramphenicol is replaced by a methylsulfone group, and its antibacterial spectrum is similar to that of chloramphenicol. Thiamphenicol is mainly excreted from the kidneys, and the active concentration in urine is higher than that of chloramphenicol. Therefore, the dose should be reduced when the renal function is poor. Although there are hematological toxicity, they are all reversible changes, and aplastic anemia does not occur. Some countries believe that its efficacy is superior to chloramphenicol, but China believes that its efficacy is not superior to chloramphenicol.