Apixaban Impurity 503615-03-0 CAS NO.503615-03-0

Product Name:	3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Synonyms:	3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone;5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone;Apixaban Intermediate3;5-morpholin-4-yl-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one;3-(Morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one (Nitro MPDP);3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one;Apixaban Impurity 19;5-morpholino-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one
CAS:	503615-03-0
MF:	C15H17N3O4
MW:	303.31
EINECS:	123-548-3
Product Categories:	503615-03-0
Mol File:	503615-03-0.mol

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Chemical Properties

Boiling point	506.5±50.0 °C(Predicted)
density	1.356
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
pka	3.11±0.20(Predicted)
form	Solid
color	Light Yellow

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Usage And Synthesis

Description	3-(4-Morpholinyl)-1-(4-nitrophenyl)-5, 6-dihydro-2(1H)-pyridinone is the intermediate for the synthesis of apixaban, which is an anticoagulant for the treatment of venous thromboembolic events.
References	Chao, H. E., et al. "Synthesis of Apixaban." Chinese Journal of Pharmaceuticals (2014). #
Uses	3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one is a reagent in the synthesis of 4,5-dehydro Apixaban (D229385) an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Preparation Products And Raw materials

Preparation Products