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Top Quality 99.9% up Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid / Sitagliptin Intermediate 486460-00-8 CAS NO.486460-00-8
- FOB Price: USD: 55.00-200.00 /Kilogram Get Latest Price
- Min.Order: 2 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,
- Available Specifications:
Agrochemical Intermediate(1-99)KilogramAgrochemical Intermediate(100-999)Metric TonAgrochemical Intermediate(1000-9999)Kilogram
- Product Details
Keywords
- Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid
- Sitagliptin Intermediate 486460-00-8
- Sitagliptin Intermediate
Quick Details
- ProName: Top Quality 99.9% up Boc-(R)-3-Amino-4...
- CasNo: 486460-00-8
- Molecular Formula: C15H18F3NO4
- Appearance: White powder
- Application: Intermediates, Flavor & Fragrance Inte...
- DeliveryTime: in 7 days after your payment
- PackAge: 1kg/bag ;5kg/drum:25KG/drum
- Port: any port in China
- ProductionCapacity: 20 Metric Ton/Month
- Purity: 99% up
- Storage: in low tempreture
- Transportation: in low tempreture
- LimitNum: 2 Kilogram
Superiority
Why is SINOWAY:
1) Specialized in pharmaceutical and healthcare industrial for 34 years.
2) ISO 9001:2015 & SGS audited supplier .
3) Accept various payment terms : T.T 30-60 days.
4) We have warehouse in USA with quickly shipment .
5) We can do different terms of FOB ,CIF/CIP ,DDP ...
FAQ
Q: How to start orders or make payments
A: You can send us your Purchase order(PO), or just send a simple confirmation by email or by Trade Manager, after communication then we will send you Proforma Invoice with our bank details for final confirmation, then you
can make payment accordingly.
Q: What’s our Minimun Ordering Quantity (MOQ)
A: For the high value products, our MOQ starts from 1 gram and other products generally starts from 1 kilogram. For other low value products, MOQ can be started from 10kgs to 100kgs.
Q: How do we guarantee our products quality
A: First of all, our quality control system will reduce our quality problem to near zero.We can always provide our certificate of analysis according to every batch of our products.We can also provide third party analysis testing due to our clients' requirement.
If there is any quality issue caused by us, we will send you free goods for replacement or refund your loss.
Q: How to contact us
A: You can contact us thought inquiries to message box of any of our products displayed or contact us online on Trade Manager on Alibaba. You can also sent us emails to our company email address or simply call us at anytime!
Details
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Product name |
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Sitagliptin intermediate |
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CAS No. |
486460-00-8 |
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Molecular Formula |
C15H18F3NO4 |
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Molecular Weight |
333.307 |
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Quality Standard |
98% up by HPLC |
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Appearance |
White to off-white powder |
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ITEMS |
SPECIFICATION |
RESULT |
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Appearance |
White to off-white powder |
Conforms |
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Water content by KF |
≤ 0.50% |
0.12% |
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Identity |
IR: Conforms to spectrum of the standard |
Conforms |
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HPLC Conforms to retention time of the standard |
Conforms |
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Specific rotation |
+13.0。~ +18.0。 |
+13.6。 |
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Stereochemical purity by HPLC -S-isomer |
≤ 0.10% |
0.01% |
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Related substances by HPLC |
3-amino-4-(2,4,5-trifluorophenyl)butanoic acid ≤ 0.10% |
0.06% |
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Largest unknown impurity ≤ 0.30% |
0.05% |
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Total impurities ≤ 0.50% |
0.11% |
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Solvent residue by GC |
Ethyl acetate ≤ 500ppm |
74 ppm |
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Heptane ≤ 500ppm |
78 ppm |
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Methanol ≤ 300ppm |
35 ppm |
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Toluene ≤ 89ppm |
ND |
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Acetonitrile ≤ 41ppm |
ND |
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Residue on ignition |
≤ 0.50% |
0.04% |
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Metal residue Rh |
≤ 10ppm |
< 10ppm |
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Assay(By Anhydrous base) |
98.0～102.0% |
100.1% |
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Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid is one of key intermediates of Sitagliptin.
Physical properties of Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid:
(1)ACD/LogP: 2.341;
(2)# of Rule of 5 Violations: 0;
(3)ACD/LogD (pH 5.5): 0.98;
(4)ACD/LogD (pH 7.4): -0.78;
(5)ACD/BCF (pH 5.5): 1.55;
(6)ACD/BCF (pH 7.4): 1.00;
(7)ACD/KOC (pH 5.5): 19.59;
(8)ACD/KOC (pH 7.4): 1.00;
(9)#H bond acceptors: 5;
(10)#H bond donors: 2;
(11)#Freely Rotating Bonds: 7;
(12)Index of Refraction: 1.494;
(13)Molar Refractivity: 75.072 cm3;
(14)Molar Volume: 257.776 cm3;
(15)Surface Tension: 40.6020011901855 dyne/cm;
(16)Density: 1.293 g/cm3;
(17)Flash Point: 221.754 °C;
(18)Enthalpy of Vaporization: 73.842 kJ/mol;
(19)Boiling Point: 443.058 °C at 760 mmHg;
(20)Vapour Pressure: 0 mmHg at 25°C.