The intermediate of Dabigatran 2498-50-2 CAS NO.2498-50-2

Product Name:	4-Aminobenzamidine dihydrochloride
Synonyms:	4-AMINOBENZAMIDINE DIHYDROCHLORIDE;4-AMINOBENZAMIDINE HCL SALT;BENZENECARBOXIMIDAMIDE, 4-AMINO-, DIHYDROCHLORIDE;P-AMINOBENZAMIDINE DIHCL;P-AMINOBENZAMIDINE DIHYDROCHLORIDE;4-Aminobenzamidine HCl;4-AMINOBENZAMIDINE DIHYDROCHLORIDE, FOR FLUORESCENCE;4-Aminobenzamidine2HCl
CAS:	2498-50-2
MF:	C7H11Cl2N3
MW:	208.09
EINECS:	219-692-2
Product Categories:	inhibitor;Imines/AmidinesFluorescent Probes, Labels, Particles and Stains;Anilines, Aromatic Amines and Nitro Compounds;Nitrogen Compounds;Organic Building Blocks;Other Fluorescent Labels;Amines;Miscellaneous;Broad Spectrum Inhibitors of Proteolytic Enzyme Classes;Other Fluorescent LabelsEnzyme Inhibitors;Protease InhibitorsFluorescent Stains;Protein Stains;Protein Stains For SpectroscopyProtease Inhibitors;Serine Protease Inhibitors;Fluorescent Labels;Fluorescent Probes, Labels, Particles and Stains;Protease Inhibitors
Mol File:	2498-50-2.mol

4-Aminobenzamidine dihydrochloride Chemical Properties

Melting point	>300 °C(lit.)
storage temp.	2-8°C
solubility	DMSO (Slightly), Water
form	Fine Crystalline Powder
color	White to yellow
Sensitive	Hygroscopic
BRN	3692927
Stability:	Hygroscopic
InChIKey	GHEHNICLPWTXJC-UHFFFAOYSA-N
CAS DataBase Reference	2498-50-2(CAS DataBase Reference)

Safety Information

4-Aminobenzamidine dihydrochloride Usage And Synthesis

Chemical Properties	white to yellowish fine crystalline powder
Uses	4-Aminobenzamidine dihydrochloride is a synthetic diamidine derivative that acts as a urokinase inhibitor as well as trypsin inhibitor. It is used as a ligand in affinity chromatography for purification and immobilization of enzymes.
Application	4-Aminobenzamidine dihydrochloride can be used to synthesize: Orally active fibrinogen receptor antagonists based on benzamidines. Benzamidine derivatives that are selective and potent serine protease inhibitors. Novel pyrrolo [3,2-c] quinolines that are structural analogs of topoisomerase inhibitors such as coralyne and fagaronine. Synthesis of a selective inhibitor of PRMT1 (SKLB-639)
Preparation	4-Aminobenzamididine dihydrochloride is obtained by cyanation, addition, amination and reduction of 4-nitrobenzoic acid.
Definition	ChEBI: P-Aminobenzamidine dihydrochloride is an organic molecular entity.

4-Aminobenzamidine dihydrochloride Preparation Products And Raw materials

Raw materials	Ethanol-->Hydrochloric acid-->Methanol-->Sodium-->Acetone-->Palladium-->Ammonium chloride-->Iron-->Sodium Methoxide-->Tin-->Stannous chloride-->4-Nitrobenzoic acid-->Tetrabutylammonium fluoride-->Benzhydrylamine-->Ferrous sulfide-->4-Nitrobenzonitrile-->Benzenecarboximidic acid, 4-nitro-, methyl ester
Preparation Products	Dabigatran Etexilate iMpurity I