Amiodarone 19774-82-4 CAS NO.19774-82-4

Ketone,2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl,hydrochloride (7CI,8CI)
Amiodarone hydrochloride
19774-82-4

Product Name:	Amiodarone hydrochloride
Synonyms:	2-BUTYL-3-BENZOFURANYL 4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL KETONE HYDROCHLORIDE;(2-BUTYL-3-BENZOFURANYL)-[4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODO-PHENYL]-METHANONE HYDROCHLORIDE;AMIODARONE-D4 HCL;AMIODARONE HCL;AMIODARONE HYDROCHLORIDE;AMIODARONUM HYDROCHLORIDE;2-butyl-3-benzofuryl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride;AMIODARONEHCL(2-BUTYL-3-BENZOFURANYL-4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYLKETONE)
CAS:	19774-82-4
MF:	C25H29I2NO3.ClH
MW:	681.77
EINECS:	243-293-2
Product Categories:	API;API's;Ion transporter and other ion channel;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Active Pharmaceutical Ingredients;19774-82-4
Mol File:	19774-82-4.mol

Amiodarone hydrochloride Chemical Properties

Melting point	154-158°C
Fp	9℃
storage temp.	2-8°C
solubility	Soluble in chloroform, methanol.
pka	pKa (25°C) 6.56 ±0.06
form	Solid
color	White
λmax	242nm(MeOH)(lit.)
Merck	14,482
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Amiodarone hydrochloride Usage And Synthesis

Description	Amiodarone HCl (19774-82-4) is a nonselective ion channel blocker. Class III antiarrhythmic.1 Induces cytochrome c release and induces apoptosis.2 An alkalizing agent which stimulates progranulin (GRN) production and prevents GRN-dependent neurodegeneration.3 Induces autophagy and suppresses hepatocellular carcinoma tumorigenesis via autophagy-mediated MIR224 degradation in vitro and in vivo.4
Chemical Properties	White Solid
Originator	Cordarone,Labaz,France,1971
Uses	Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
Uses	Antiarrhythmic;Na+ channel blocker
Uses	A non-selective ion channel blocker. Antiarrhythmic (class III)
Uses	Amiodarone hydrochloride is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca²⁺ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. Amiodarone hydrochloride has also been used in a study to determine concentrations of thyroid disrupting substances in effluents from wastewater treatment plants.