China (Mainland)
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Antivirus API powder Lopinavir CAS NO.192725-17-0
- Min.Order: 25 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T,Other
- Product Details
Keywords
- Lopinavir CAS:192725-17-0
- Lopinavir
- USP standard Lopinavir with 99% up
Quick Details
- ProName: Antivirus API powder Lopinavir
- CasNo: 192725-17-0
- Molecular Formula: C37H48N4O5
- Appearance: white powder
- Application: Lopinavir is used in combination with ...
- DeliveryTime: within 15 days after order
- PackAge: 25kg/drum
- Port: Beijing/Shanghai/Hangzhou/Shenzhen
- ProductionCapacity: 1000 Kilogram/Month
- Purity: 99% up
- Transportation: by air, by sea or courier
- LimitNum: 25 Kilogram
- Related Substances: Total?impurity ≤1.0%
- Residue on Ignition: ≤0.1%
- Heavy Metal: ≤10ppm
- Valid Period: 2 years
- Loss on drying: ≤0.5%
Superiority
1) Specialized in pharmaceutical industry since from 1987
2) ISO 9001:2015 & SGS audited supplier
3) Accept better payment terms : T.T 30-60 days.on the basic of pass SINOSURE credit investigation.
5) We have warehouse in USA with quickly shipment .
6) We can do different terms of FOB ,CIF/CIP ,DDP ...
Details
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Company Information |
Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc..
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Product Information |
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Product name |
Lopinavir |
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CAS No. |
192725-17-0 |
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Molecular Formula |
C37H48N4O5 |
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Molecular Weight |
628.801 |
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Quality Standard |
99% up, USP42, Medicine Grade |
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Appearance |
White powder |
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COA of Lopinavir |
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TEST |
SPECIFICATION |
RESULTS |
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Description |
White powder |
Complies |
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Identification |
IR |
Complies |
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HPLC |
Complies |
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Heavy metal |
≤10ppm |
5ppm |
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Pb |
≤3ppm |
1.5ppm |
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Hg |
≤0.1ppm |
0.05ppm |
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Cd |
≤1ppm |
0.2ppm |
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Loss on drying |
≤0.5% |
0.12 |
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Residue on lgnition |
≤0.1% |
0.03 |
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Single impurity |
≤0.5% |
0.12 |
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Total impurity |
≤1.0% |
0.29 |
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Total bacteria |
≤1000cfu/g |
<1000 |
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Yeast and Mould |
≤100 cfu/g |
<000 |
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E.coli/25g |
Absent |
Absent |
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Salmonella/25g |
Absent |
Absent |
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Assay |
≥99.0% |
99.4% |
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Conclusion |
Conforms with USP/EP standards |
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Usage |
Function of Lopinavir
Lopinavir is used in combination with other antiretroviral drugs to treat human immunodeficiency virus-1 (HIV-1) infection in adults and children over 2 years old.
Lopinavir is an HIV protease inhibitor, which can block the division of Gag-Pol polyprotein, resulting in the production of immature, non-infectious virus particles; ritonavir is a kind of HIV-1 and HIV- 2 Peptidomimetic inhibitors of aspartyl protease activity. By inhibiting HIV protease, the enzyme cannot process the precursor of Gag-Pol polyprotein, resulting in the formation of immature HIV particles, which prevents the start of a new infection cycle. Ritonavir can inhibit CYP3A-mediated metabolism of lopinavir, resulting in a higher concentration of lopinavir.
Antiviral activity of Lopinavir: In vitro antiviral drug activity studies in combination with lopinavir have shown that the combination of lopinavir and nelfinavir will increase the antagonistic effect, and it can be compared with amprenavir, atazanavir and indinavir The combined application of Vivi, Saquinavir and Telanavir will increase the synergy. The EC50 value of lopinavir for three different HIV-2 virus strains is between 12~180nM (0.008~113 μg/mL).
