China (Mainland)
99% up GMP DMF Calcium Folinate 1492-18-8 CAS NO.1492-18-8
- Min.Order: 25 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T
- Product Details
Keywords
- Calcium Folinate
- Folinate
- 1492-18-8
Quick Details
- ProName: 99% up GMP DMF Calcium Folinate 1492-1...
- CasNo: 1492-18-8
- Molecular Formula: C20H21CaN7O7
- Appearance: White powder
- Application: anti-HIV, anti-HBV
- DeliveryTime: in 7 days after your payment
- PackAge: 1kg/bag ;25kg/drum
- Port: Shanghai/Beijing/Hangzhou
- ProductionCapacity: 10 Metric Ton/Month
- Purity: 99.5% up
- Storage: Dry place
- Transportation: dry place
- LimitNum: 25 Kilogram
Superiority
Why is SINOWAY:
1) Specialized in pharmaceutical and healthcare industrial for 34 years.
2) ISO 9001:2015 & SGS audited supplier .
3) Accept various payment terms : T.T 30-60 days.
4) We have warehouse in USA with quickly shipment .
5) We can do different terms of FOB ,CIF/CIP ,DDP ...
Details
|
Product name |
Calcium folinate |
|
CAS No. |
1492-18-8 |
|
Molecular Formula |
C20H21N7O7.Ca |
|
Molecular Weight |
511.507 |
|
Molecular Structure |
|
|
Quality Standard |
99% up by HPLC |
|
Appearance |
White or light yellow crystalline powder |
|
|
|
ANALYSIS |
SPECIFICATION |
RESULTS |
|
Appearance |
White or light yellow crystalline powder |
Conforms |
|
Loss on dying |
≤1.0% |
0.09% |
|
Residue on ignition |
≤0.5% |
0.1% |
|
Total impurities |
≤1.0% |
<0.07% |
|
Single impurity |
≤0.5% |
0.05% |
|
Assay(by HPLC) |
99.0% up |
99.7% |
|
Conclusion |
The product meets the in-house specification |
|
|
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What is Calcium folinate
Calcium folinate (called Folinic acid or calcium leucovorin also) is the calcium salt of 5-formyl tetrahydrofolic acid. It is an active metabolite of folinic acid and an essential coenzyme for nucleic acid synthesis in cytotoxic therapy. Calcium folinate is frequently used to diminish the toxicity and counteract the action of folate antagonists, such as methotrexate.
Folinic acid is a medication used in the treatment of various cancers in combination with 5-FU. It is also commonly used as an antidote to folic acid antagonists such as methotrexate. Folinic acid (leucovorin) is an antidote, chemotherapy modulating agent, and rescue agent for the chemotherapy class of medications.5-FU administration reduces deoxythymidine monophosphate, blocks DNA synthesis, and causes cell death. Calcium folinate stabilizes the complex between 5-FU and thymidylate synthase and thus augments 5-FU cytotoxicity.
