factory supply GMP,DMF Deflazacort CAS NO.14484-47-0

Min.Order: 1 Kilogram
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Deflazacort
Denazacort
14484-47-0

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ProName: factory supply GMP,DMF Deflazacort
CasNo: 14484-47-0
Molecular Formula: C15H18
Appearance: White crystallization
Application: Cardiovascular APIs,Sartan antihyperte...
DeliveryTime: in two weeks
PackAge: 25kg/drum
Port: SHANGHAI BEIJING
ProductionCapacity: 10 Metric Ton/Day
Purity: USP/EP/BP
Storage: room temperature
Transportation: AIR SEA TRAIN
LimitNum: 1 Kilogram

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We are very compeitive on Deflazacort.Our mfr is GMP certified for this item with DMF document.

Product Name:	Deflazacort
Synonyms:	16-d)oxazole-3,20-dione,11-beta,21-dihydroxy-2’-5’-beta-h-pregna-4-dieno(17;azacort;calcort;deflan;(5'β)-11β-Hydroxy-21-acetyloxy-2'-methyl-1,2,4,5-tetradehydropregnano[17,16-d]oxazole-3,20-dione;(5'β)-21-Acetyloxy-11β-hydroxy-2'-methylpregnano[17,16-d]oxazole-1,4-diene-3,20-dione;11b,21-Dihydroxy-2'-;Denazacort
CAS:	14484-47-0
MF:	C25H31NO6
MW:	441.52
EINECS:	238-483-7
Product Categories:	CALCORT;Steroid and Hormone;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol File:	14484-47-0.mol

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Description	Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. It belongs to a group of medicines called corticosteroids. It is sometimes referred to simply as an oral steroid. Deflazacort is an inactive prodrug which is metabolized rapidly to the active drug 21-desacetyldeflazacort.It is used to treat a wide variety of conditions. Some examples include autoimmune diseases (for example, systemic lupus erythematosus (SLE), autoimmune hepatitis, sarcoidosis), joint and muscle diseases (for example, rheumatoid arthritis), and allergies and asthma. Cardiff can be specially designed for the third generation of corticosteroids, anti-inflammatory, anti-allergy, and it increased gluconeogenesis and so on. It acts as prednisolone 10~20 times of the dragon, 40 times as hydrocortisone. This product has no mutagenic effect. This product, labeled with C14 study, shows that the product of the gastrointestinal tract rapidly absorbed, reaching the peak blood concentration after 1~2h, forming the active substance by hydrolysis, and the latter further metabolic processes is similar with other corticosteroids, as well as the active metabolite T1/2 is 2 h and the rats are mainly distributed in the kidney and hematopoietic system and other organizations. Figure 1 is a deflazacort formula.
Chemical Properties	Acetone-hexane, m.p. 255-256.5 ℃. [Α] D + 62.3 ° (C = 0.5, chloroform). UV absorption maximum (methanol): 241~242nm (E1cm1% 352.5). Acute toxicity LD50 in mice (mg/kg): 5200 oral; 1610 subcutaneous injection. Rats Acute toxicity LD50 (mg/kg): 109 subcutaneously. Dog Acute toxicity LD50 (mg/kg):> 4000 Oral; 50 subcutaneous injection.
Application	The third generation of corticosteroids, anti-inflammatory, anti-allergy, increased gluconeogenesis and so on. For the use of the primary and secondary adrenocortical insufficiency, rheumatism, collagen diseases, skin diseases, allergic diseases, eye diseases, and fulminant disseminated tuberculosis, hematopoietic system disorders, ulcerative colitis, idiopathic nephrotic syndrome, and other hematopoietic malignancies.

factory supply GMP,DMF Deflazacort CAS NO.14484-47-0

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