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99% up by HPLCCaspofungin Intermediate Pneumocandin B0 135575-42-7 CAS NO.135575-42-7
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T
- Product Details
Keywords
- Caspofungin Intermediate
- Pneumocandin B0
- Pneumocandin
Quick Details
- ProName: 99% up by HPLCCaspofungin Intermediate...
- CasNo: 135575-42-7
- Molecular Formula: C50H80N8O17
- Appearance: White or almost white hygroscopic powd...
- Application: API
- DeliveryTime: 7 working days
- PackAge: 25kg per drum
- Port: shanghai/beijing/hangzhou
- ProductionCapacity: 1000 Kilogram/Month
- Purity: 99.9%
- Storage: Normal temperature
- Transportation: normal temperature.
- LimitNum: 1 Kilogram
Superiority
Why is SINOWAY:
1) Specialized in pharmaceutical and healthcare industrial for 34 years.
2) ISO 9001:2015 & SGS audited supplier .
3) Accept various payment terms : T.T 30-60 days.
4) We have warehouse in USA with quickly shipment .
5) We can do different terms of FOB ,CIF/CIP ,DDP ...
Details
|
Product name |
Caspofungin intermediate / Pneumocandin B0 |
|
CAS No. |
135575-42-7 |
|
Molecular Formula |
C50H80N8O17 |
|
Molecular Weight |
1065.23 |
|
Quality Standard |
97% up by HPLC |
|
Appearance |
White to off-white powder |
|
ITEMS |
SPECIFICATION |
RESULT |
|
Appearance |
Yellowish or white powder |
Conforms |
|
Water |
≤ 9.0% |
4.53% |
|
Identity |
FT- IR Correspond to the standard |
Conforms |
|
HPLC retention time Correspond to the standard |
Conforms |
|
|
Chromatographic Purity |
Pneumocandin A0 (PNA) ≤ 0.10% IP-1 ≤ 1.5% IP-2 ≤ 1.5% IP-3 ≤ 1.5% Pneumocandin C0 (PNC) ≤ 0.30% Any individual unspecified impurities ≤ 0.50% Total impurities (including PNC) ≤ 6.0% |
0.07% 0.36% Not detected 0.08% 0.07% 0.25% max 1.21% |
|
Assay (on anhydrous basis) |
≥ 94.0% |
97.6% |
|
Related solvents |
Methanol ≤ 3000ppm Ethanol ≤ 5000ppm 2-propanol ≤ 5000ppm Dichloromethane ≤ 600ppm |
Not detected Not detected 393ppm Not detected |
|
Conclusion |
The product complies with the in-house specification |
|
What is Pneumocandin B0
Pneumocandin B0 is a new class of cyclolipopeptide natural antifungal drugs produced by fermentation of filamentous fungi. It has a cyclic hexapeptide core and a fatty acid side chain structure. and Pneumocystis carinii are effective, so more and more people's attention. The cyclic hexapeptide core after removing the fatty acid side chain of Numeroctin B0 is the main raw material for the synthesis of Caspofungin.
Function of Caspofungin
Caspofungin is the first marketed echinocandin in the world. Its mechanism of action is unique. It targets the fungal cell wall and specifically inhibits the synthesis of β(1,3)-d-glucan in the cell wall and destroys the fungal cell wall. The integrity of the fungal cells makes the intracellular osmotic pressure unstable, which eventually leads to the lysis of the fungal cells. Mammalian cells do not contain -β-(1,3)-glucan, and there is no similar cell wall synthesis process. Therefore, while caspofungin is antifungal, it will not damage and affect human cells. In vitro pharmacological studies have shown that caspofungin is effective against a variety of Candida, endemic fungi, Aspergillus and Pneumocystis carinii, so it has attracted more and more attention. Pneumocandin B0 is a new class of cyclolipopeptide natural antifungal drugs produced by fermentation of filamentous fungi. It has a cyclic hexapeptide core and a fatty acid side chain structure. and Pneumocystis carinii are effective, and more and more people's attention.