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Home > Products >  Midostaurin 120685-11-2

Midostaurin 120685-11-2 CAS NO.120685-11-2

  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,T/T,Other
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  • Product Details

Keywords

  • Benzamide,N-(2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-,[9S-(9a,10b,11b,13a)]-
  • 120685-11-2
  • Midostaurin

Quick Details

  • ProName: Midostaurin
  • CasNo: 120685-11-2
  • Molecular Formula: C35H30N4O4
  • Appearance: White crystallization
  • Application: oral anticoagulant drug
  • DeliveryTime: in two weeks
  • PackAge: 25kg/drum
  • Port: SHANGHAI BEIJING
  • ProductionCapacity: 10 Metric Ton/Day
  • Purity: USP/EP/BP
  • Storage: room temperature
  • Transportation: AIR SEA TRAIN
  • LimitNum: 1 Kilogram

Superiority

Product Name: Midostaurin
Synonyms: CGP 41251MIDOSTAURIN(PKC412);N-((5S,6R,7R,9R)-6-Methoxy-14-oxo-5,6,7,8,9,14,15,16-octahydro-17-oxa-4b,9a,15-triaza-5,9-Methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-MethylbenzaMide;PKC-412, CGP-41251;Midostaurin (PKC412);PKC412 (Midostaurin);CGP 41231;N-Benzoylstaurosporine;(Midostaurin) Benzoylstaurosporine
CAS: 120685-11-2
MF: C35H30N4O4
MW: 570.64
EINECS: 999-999-2
Product Categories: antibiotic;Pharmaceutical
Mol File: 120685-11-2.mol
Midostaurin Structure
 
Midostaurin Chemical Properties
Melting point  235-260℃
density  1.47±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100% ethanol (2.5 mg/ml), and DMF (20 mg/ml).
form  Tan solid
pka 14.19±0.70(Predicted)
color  White
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
 
Safety Information
Hazard Codes  T
Risk Statements  36/37/38
HS Code  29329990

Details

Description PKC-412 (120685-11-2) is a broad spectrum kinase inhibitor. Inhibited kinases include, but are not limited to; PKA, PKC, S6 Kinase, KDR, PKC, Akt, EGFR, VEGFR, PDGFR, c-kit, and FLT-3. Acute myeloid leukemia related mutant forms of FLT-3 are also inhibited both in vitro and in vivo. PKC-412 has been demonstrated to induce apoptosis and shows broad antiproliferative activity in various tumor cell lines. Cell Permeable
Uses Midostaurin is used as a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Due to this act which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors. Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.

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