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98% up by HPLC Tacrolimus FK-506 104987-11-3 CAS NO.104987-11-3
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T
- Product Details
Keywords
- Tacrolimus
- FK-506
- 104987-11-3
Quick Details
- ProName: 98% up by HPLC Tacrolimus FK-506 10498...
- CasNo: 104987-11-3
- Molecular Formula: C44H69NO12
- Appearance: White powder
- Application: API anticancer
- DeliveryTime: in 7 days after your payment
- PackAge: 1kg/bag ;25kg/drum
- Port: Shanghai/Beijing/Hangzhou
- ProductionCapacity: 10 Metric Ton/Month
- Purity: 98% up
- Storage: Dry place
- Transportation: cool&dry
- LimitNum: 1 Kilogram
Superiority
Why is SINOWAY:
1) Specialized in pharmaceutical and healthcare industrial for 34 years.
2) ISO 9001:2015 & SGS audited supplier .
3) Accept various payment terms : T.T 30-60 days.
4) We have warehouse in USA with quickly shipment .
5) We can do different terms of FOB ,CIF/CIP ,DDP ...
Details
|
Product name |
Tacrolimus ; FK-506 |
|
CAS No. |
104987-11-3 |
|
Molecular Formula |
C44H69NO12 |
|
Molecular Weight |
804.02 |
|
Quality Standard |
98% up by HPLC |
|
Appearance |
White or light yellow powder |
|
Items |
Specifications |
Results |
|
Appearance |
White or light yellow powder |
White or light yellow powder |
|
Assay |
98%-102% |
99.1% |
|
Water |
≤ 3.0% |
2.5% |
|
Related substances |
Ascomycin ≤ 0.8% |
0.05% |
|
Dihydrotacrolimus ≤ 0.6% |
0.3% |
|
|
Total Impurities ≤ 1.5% |
0.43% |
|
|
Residual solvents |
Acetone ≤ 2000ppm |
ND |
|
Ethanol ≤ 2000ppm |
ND |
|
|
Heavy metals |
≤ 20ppm |
< 20ppm |
|
Single impurity |
≤ 0.6% |
0.2805% |
|
Total impurity |
≤ 1.5% |
0.33% |
|
Conclusion |
Meet the specifications |
|
Function of Tacrolimus
Tacrolimus (FK506), a macrolide, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase (calcineurin phosphatase), thereby inhibiting T lymphocyte signal transduction and IL-2 transcription, with strong Immunosuppressive properties. In recent years, as a first-line drug for liver and kidney transplantation, it has been marketed in 14 countries including Japan and the United States. Clinical experiments show that it has a good effect in transplantation of heart, lung, intestine, bone marrow, etc. At the same time, FK506 also plays an active role in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune diseases.
