China (Mainland)
Diamondsupplier 
99% up by HPLC 6-Benzofurancarboxylic Acid 77095-51-3 CAS NO.77095-51-3
- Min.Order: 1 Kilogram
- Payment Terms: L/C,D/A,D/P,T/T
- Product Details
Keywords
- 6-Benzofurancarboxylic Acid
- lifitegrast intermediate
- 77095-51-3
Quick Details
- ProName: 99% up by HPLC 6-Benzofurancarboxylic ...
- CasNo: 77095-51-3
- Molecular Formula: C9H6O3
- Appearance: White or almost white hygroscopic powd...
- Application: API
- DeliveryTime: 7 working days
- PackAge: 25kg per drum
- Port: shanghai/beijing/hangzhou
- ProductionCapacity: 1000 Kilogram/Month
- Purity: 99.9%
- Storage: Normal temperature
- Transportation: normal temperature.
- LimitNum: 1 Kilogram
Superiority
Why is SINOWAY:
1) Specialized in pharmaceutical and healthcare industrial for 34 years.
2) ISO 9001:2015 & SGS audited supplier .
3) Accept various payment terms : T.T 30-60 days.
4) We have warehouse in USA with quickly shipment .
5) We can do different terms of FOB ,CIF/CIP ,DDP ...
Details
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6-Benzofurancarboxylic acid is one of the key intermediates of Lifitegrast.
Function of Lifitegrast
Lifitegrast is a leukocyte function antigen 1 antagonist used in the treatment of dry eye. Lifitegras can bind to leukocyte functional antigen 1 (LFA-1), preventing the binding of LFA-1 to its cognate ligand intercellular adhesion molecule-1 (ICAM-1). ICAM-1 is overexpressed in the corneal Chemicalbook membrane and conjunctival tissues of patients with dry eye, and LFA-1 binds to ICAM-1 to promote the formation of immune synapses, leading to activation of T cells and migration to target tissues. In vitro studies have shown that Lifitegrast can inhibit T cell adhesion to ICAM-1 and also inhibit the secretion of inflammatory cytokines in human peripheral blood mononuclear cells.