Ponazuril 69004-04-2 CAS NO.69004-04-2

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Product Name:	Ponazuril
Synonyms:	Toltrazuril sulfone Ponazuril;1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H;Ponazuril;ToltrazurilSulfone;1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione;Ponazuril [inn];Unii-jpw84as66u;1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
CAS:	69004-04-2
MF:	C18H14F3N3O6S
MW:	457.38
EINECS:	629-740-8
Product Categories:	Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	69004-04-2.mol

Ponazuril Chemical Properties

Melting point	242°
density	1.507±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	6.46±0.20(Predicted)
form	Solid
color	White to Off-White
InChIKey	VBUNOIXRZNJNAD-UHFFFAOYSA-N
CAS DataBase Reference	69004-04-2

Ponazuril Usage And Synthesis

Description	Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril . Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 μg/ml. Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.
Uses	Toltrazuril sulfone is antiprotazoal, used to treat Equine Protozoal Myeloencephalitis (EPM).
Veterinary Drugs and Treatments	Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona. Ponazuril could potentially be useful in treating Neospora caninum and Toxoplasma infections in dogs or cats.