China (Mainland)
Diamondsupplier 
factory supply Apixaban Intermediate 545445-44-1 CAS NO.545445-44-1
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T,Other
- Product Details
Keywords
- Rivaroxaban
- Apixaban
- 545445-44-1
Quick Details
- ProName: factory supply Apixaban Intermediate 5...
- CasNo: 545445-44-1
- Molecular Formula: C15H18
- Appearance: White crystallization
- Application: treating pulmonary embolism and preven...
- DeliveryTime: in two weeks
- PackAge: 25kg/drum
- Port: SHANGHAI BEIJING
- ProductionCapacity: 10 Metric Ton/Day
- Purity: 99.9% by HPLC
- Transportation: AIR SEA TRAIN
- LimitNum: 1 Kilogram
- Moisture Content: ≤0.5%
Superiority
We are very compeitive on Apixaban .Our mfr is Chinese GMP certified for this item with DMF/CEP document.
| Product Name: | 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one |
| Synonyms: | 5-morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-2,3-dihydropyridin-6-one;3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one;3-Morpholino-1-(4-(2-oxopiperidin-1-yl);HSK00001094;Apixaban Impurity H;Apixaban Intermediates;Apixaban Impurity P;3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one |
| CAS: | 545445-44-1 |
| MF: | C20H25N3O3 |
| MW: | 355.43 |
| EINECS: | 1308068-626-2 |
| Product Categories: | |
| Mol File: | 545445-44-1.mol |
| 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Chemical Properties |
| Melting point | >199°C (dec.) |
| Boiling point | 625.0±55.0 °C(Predicted) |
| density | 1.267 |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.25±0.20(Predicted) |
| color | Pale Beige |
Details
| Uses | 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropy can be used as an organic synthesis intermediate, mainly used in laboratory research and development and chemical production processes. |
| Synthesis | 2 g compound C (compound Ib) and 50 ml acetonitrile were added into a three-necked flask to obtain a turbid solution. The turbid solution was stirred and cooled to 0 C. in an ice bath. 1.75 g (6 eq) sodium hydroxide was added and stirred in the ice bath for 10 min. Then 1.9 ml of 5-chloro-valeryl chloride (2 eq) (diluted with 2 ml acetonitrile) was dropwise added while controlling the temperature to 0-5 C. After completing the addition, the ice bath was removed and the temperature was naturally raised to 30 C. The reaction was performed for 5 hours. After observing the absence of the starting material and the intermediate state of the reaction, the reaction solution was cooled to 0 C. in an ice bath, and adjusted to a neutral pH with 6 N of hydrochloric acid. The reaction solution was concentrated to dryness, pulpifying for 1 hour after adding 8 ml saturated sodium bicarbonate solution, and filtered to obtain 2.29 g yellow solid. Yield: 87.5%. Purity: 95.3% (HPLC). EI-MS (m/z): 355.2. HNMR (400 MHz, DMSO, ppm) | 7.32 (d, J=8.8 Hz, 2H), 7.26 (d, J=8.8 Hz, 2H), 5.71 (t, J=4.8 Hz, 1H), 3.72-3.69 (m, 2H), 3.65-3.63 (m, 4H), 3.60-3.57 (m, 2H), 2.79-2.77 (m, 4H), 2.44-2.41 (m, 2H), 2.40-2.39 (m, 2H), 1.88-1.82 (m, 4H). |