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Product Name:	Lestaurtinib
Synonyms:	Lestaurtinib (KT-5555;CS-1165;lestaurtinib;(9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxyMethyl)-9-Methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one;SPM-924;CEP-701 hydrate;KT-5555 hydrate;Lestaurtinib hydrate
CAS:	111358-88-4
MF:	C26H21N3O4
MW:	439.47
EINECS:
Product Categories:	Inhibitor;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	111358-88-4.mol

Description	Lestaurtinib (111358-88-4) is a potent and selective FLT3 inhibitor (IC50= 2 nM).1,2 Inhibits RET and RET phosphorylation in medullary thyroid carcinoma cells.3 Suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders.4 Potent Trk inhibitor.5 Cell permeable.
Chemical Properties	Lestaurtinib is Off-White Solid
Uses	Lestaurtinib is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML)
Uses	It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).
Uses	CEP-701 hydrate has been used as a tyrosine kinase inhibitor: to study its effects on early growth response protein (EGR) genes and nerve growth factor (NGF) stimulation in human epithelial cells as a supplement in reservoir solution for co-crystallization studies with human receptor-interacting protein kinase 4 (RIPK4) as an FMS-like tyrosine kinase 3 (FLT3) inhibitor-gold nanoparticle conjugate to study its effects on acute myeloid leukemia