| Chloramphenicol Chemical Properties |
| Melting point |
148-150 °C(lit.) |
| alpha |
19.5 º (c=6, EtOH) |
| Boiling point |
644.9±55.0 °C(Predicted) |
| density |
1.6682 (rough estimate) |
| refractive index |
20 ° (C=5, EtOH) |
| Fp |
14 °C |
| storage temp. |
Keep in dark place,Inert atmosphere,2-8°C |
| solubility |
absolute ethanol: soluble5-20mg/mL (as a stock solution) |
| pka |
11.03±0.46(Predicted) |
| form |
powder |
| color |
white |
| Water Solubility |
2.5 g/L (25 º C) |
| Merck |
14,2077 |
| BRN |
2225532 |
| InChIKey |
WIIZWVCIJKGZOK-RKDXNWHRSA-N |
| CAS DataBase Reference |
56-75-7(CAS DataBase Reference) |
| NIST Chemistry Reference |
Chloramphenicol(56-75-7) |
| IARC |
2A (Vol. Sup 7, 50) 1990 |
| EPA Substance Registry System |
Chloramphenicol (56-75-7) |
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| Chloramphenicol Usage And Synthesis |
| Description |
Chloramphenicol, also known as chlornitromycin, is a broad-spectrum, bacteriostatic antibiotic derived from Streptomyces venezuelae. It is first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. The synthetic product is racemic, also called synthomycin. Syntomycin is a mixture of chloramphenicol L-isomer and d-isomer. Because of dextroisomer antibacterial effect, the effect of synthomycin is only half of the natural products. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It is effective against several gram-positive and gram-negative bacteria and commonly used in researching protein synthesis and to select for chloramphenicol-resistant transformed cells or the bacterial CAT gene.
Chloramphenicol is a semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blocks peptide bond formation. As a result bacterial protein synthesis is blocked and impede bacterial cell proliferation. |
| Uses |
- Chloramphenicol is used for the treatment caused by typhoid bacillus, dysentery bacillus, Escherichia coli, bacillus, influenza and pneumococcal infections such as brucellosis.
- Chloramphenicol is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth.
- Chloramphenicol is used to treat serious infections in different parts of the body. It is sometimes given with other antibiotics. However, chloramphenicol should not be used for colds, flu, other virus infections, sore throats or other minor infections, or to prevent infections.
- Chloramphenicol should only be used for serious infections in which other medicines do not work. This medicine may cause some serious side effects, including blood problems and eye problems. Symptoms of the blood problems include pale skin, sore throat and fever, unusual bleeding or bruising, and unusual tiredness or weakness.
You and your doctor should talk about the good this medicine will do as well as the risks of taking it .
Chloramphenicol is available only with your doctor's prescription. |
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