factory supply GMP,DMF,CEP Candesartan CAS NO.145040-37-5

Min.Order: 1 Kilogram
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candesartan cilexetil
candesartan
145040-37-5

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ProName: factory supply GMP,DMF,CEP Candesartan
CasNo: 145040-37-5
Molecular Formula: C15H18
Appearance: White crystallization
Application: Cardiovascular APIs,Sartan antihyperte...
DeliveryTime: in two weeks
PackAge: 25kg/drum
Port: SHANGHAI BEIJING
ProductionCapacity: 10 Metric Ton/Day
Purity: USP/EP/BP
Storage: room temperature
Transportation: AIR SEA TRAIN
LimitNum: 1 Kilogram

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We are very compeitive on candesartan cilexetil .Our mfr is GMP certified for this item with CEP document.

Candesartan cilexetil is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor AT1 antagonist, candesartan. It is rapidly hydrolyzed to candesartan during gastrointestinal absorption. After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 AT1 in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.
Candesartan cilexetil can be used as pesticide and pharmaceutical intermediates.
It can be used as the raw material of antihypertensive drugs.
Candesartan is an angiotensin-receptor blocker (ARB)，Angiotensin receptor blockers effectively protect against the harmful effects of the activation of the renin-angiotensin-aldosterone system that occur with hypertension or diabetes.It may be used alone or with other agents to treat hypertension. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough.
Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.

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Product Name:	Candesartan cilexetil
CAS:	145040-37-5
MF:	C33H34N6O6
MW:	610.66
EINECS:	627-030-2
Product Categories:	Inhibitors;Heterocycles;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Antihypertensive;API;APIs;Hypertension;Candesartan
Mol File:	145040-37-5.mol

Melting point	168-170 C
Boiling point	843.3±75.0 °C(Predicted)
density	1.37±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥15mg/mL
form	powder
pka	pKa 3.55 (H2O t=25.0 I=0.025) (Uncertain);5.91(H2O t=25.0 I=0.025) (Uncertain)
color	white to beige
λmax	304nm(EtOH)(lit.)
Merck	14,1739
CAS DataBase Reference	145040-37-5(CAS DataBase Reference)

factory supply GMP,DMF,CEP Candesartan CAS NO.145040-37-5

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