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Home > Products >  Top Quality 99.9% up Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid / Sitagliptin Intermediate 486460-00-8

Top Quality 99.9% up Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid / Sitagliptin Intermediate 486460-00-8 CAS NO.486460-00-8

  • FOB Price: USD: 55.00-200.00 /Kilogram Get Latest Price
  • Min.Order: 2 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T,
  • Available Specifications:

    Agrochemical Intermediate(1-99)KilogramAgrochemical Intermediate(100-999)Metric TonAgrochemical Intermediate(1000-9999)Kilogram

  • Product Details

Keywords

  • Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid
  • Sitagliptin Intermediate 486460-00-8
  • Sitagliptin Intermediate

Quick Details

  • ProName: Top Quality 99.9% up Boc-(R)-3-Amino-4...
  • CasNo: 486460-00-8
  • Molecular Formula: C15H18F3NO4
  • Appearance: White powder
  • Application: Intermediates, Flavor & Fragrance Inte...
  • DeliveryTime: in 7 days after your payment
  • PackAge: 1kg/bag ;5kg/drum:25KG/drum
  • Port: any port in China
  • ProductionCapacity: 20 Metric Ton/Month
  • Purity: 99% up
  • Storage: in low tempreture
  • Transportation: in low tempreture
  • LimitNum: 2 Kilogram

Superiority

Why is SINOWAY:

1) Specialized in pharmaceutical and healthcare industrial for 34 years.

2) ISO 9001:2015 & SGS audited supplier . 

3) Accept various payment terms : T.T 30-60 days.

4) We have warehouse in USA with quickly shipment .

5) We can do different terms of FOB ,CIF/CIP ,DDP ...

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Details

 

 

Product name

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Sitagliptin intermediate

CAS No.

486460-00-8

Molecular Formula

C15H18F3NO4

Molecular Weight

333.307

Quality Standard

98% up by HPLC

Appearance

White to off-white powder

 

 

ITEMS

SPECIFICATION

RESULT

Appearance

White to off-white powder

Conforms

Water content by KF

 0.50%

0.12%

 

 

Identity

IR:

Conforms to spectrum of the standard

 

Conforms

HPLC

Conforms to retention time of the standard

 

Conforms

Specific rotation

+13.0~ +18.0

+13.6

Stereochemical purity by HPLC

-S-isomer

 0.10%

0.01%

 

Related substances by HPLC

3-amino-4-(2,4,5-trifluorophenyl)butanoic acid  0.10%

0.06%

Largest unknown impurity  0.30%

0.05%

Total impurities  0.50%

0.11%

 

 

Solvent residue by GC

Ethyl acetate  500ppm

74 ppm

Heptane  500ppm

78 ppm

Methanol  300ppm

35 ppm

Toluene  89ppm

ND

Acetonitrile  41ppm

ND

Residue on ignition

 0.50%

0.04%

Metal residue

Rh

 

 10ppm

 

< 10ppm

Assay(By Anhydrous base)

98.0102.0%

100.1%

 

 

 

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid is one of key intermediates of Sitagliptin.

 

 

Physical properties of  Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid:

(1)ACD/LogP: 2.341;

(2)# of Rule of 5 Violations: 0;

(3)ACD/LogD (pH 5.5): 0.98;

(4)ACD/LogD (pH 7.4): -0.78;

(5)ACD/BCF (pH 5.5): 1.55;

(6)ACD/BCF (pH 7.4): 1.00;

(7)ACD/KOC (pH 5.5): 19.59;

(8)ACD/KOC (pH 7.4): 1.00;

(9)#H bond acceptors: 5;

(10)#H bond donors: 2;

(11)#Freely Rotating Bonds: 7;

(12)Index of Refraction: 1.494;

(13)Molar Refractivity: 75.072 cm3;

(14)Molar Volume: 257.776 cm3;

(15)Surface Tension: 40.6020011901855 dyne/cm;

(16)Density: 1.293 g/cm3;

(17)Flash Point: 221.754 °C;

(18)Enthalpy of Vaporization: 73.842 kJ/mol;

(19)Boiling Point: 443.058 °C at 760 mmHg;

(20)Vapour Pressure: 0 mmHg at 25°C.

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